KEI SPR Can provide

Investigation of steric/allosteric effects 

Binding strength for molecular interactions – affinity constants

Discrimination between active and non-active molecules 

Information regarding biocompatibility with coatings

Quantitative information – total concentration of biomolecules in solution 

Specificity of the interaction

A qualitative tool for ligand screening

Complex assembly studies information 

Determination of reaction kinetics

Thermodynamic information

The ESPRIT is designed for high throughput SPR experiments. The automation allows reproducible measurements with the possibility to analyze up to 192 samples without user intervention. The double channel reference measurement can be used to correct for experimental errors and/or matrix effects. The autosampler is controlled by the liquid handling tool in the software. Samples are taken from the microwell plate and injected in the cuvette. The automatic control allows the user to run measurements continuously, unattended. The ESPRIT instrument is standard supplied with a normal cuvette, an electrochemical cuvette is optional.

The TWINGLE is designed for high quality, high accuracy measurements and is the economical choice for dual channel surface plasmon resonance measurements. The reference channel data can be used to correct for experimental errors and/or matrix effects. The TWINGLE is standard supplied with a normal cuvette, an electrochemical cuvette is optional.

The SPRINGLE is the entry-level single channel SPR instrument. It provides high performance SPR measurements at a convenient price. The SPRINGLE is ideal for fundamental research and development and is standard supplied with an electrochemical (ESPR) cuvette.

What makes us different?
The KEI SPR instruments have a flexible open cuvette system.

The cuvette has many advantages:
Sample volume independent of applicatio
Incubation time independent of sample volume
Sample incubation for 1 minute, 1 hour, 1 day or even 1 week
Only the needle tip is in contact point with the sample – no contamination
Viscosity independent – no clogging
Sample recovery possible without additional modules
Easy access for manual additions and modifications

The normal cuvette is the appropriate choice for measuring the lowest affinity binding systems as well as the highest affinity binding systems and is standard supplied with ESPRIT and TWINGLE

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